Protein kinase NII and the regulation of rDNA transcription in mammalian cells.

  title={Protein kinase NII and the regulation of rDNA transcription in mammalian cells.},
  author={Pascale B{\'e}lenguer and V{\'e}ronique Baldin and Chantal Mathieu and H. Prats and M Bensaid and G{\'e}rard Bouche and François Amalric},
  journal={Nucleic acids research},
  volume={17 16},
Transcription of ribosomal RNA genes is generally accepted to correlate with cell growth. Using primary cultures of adult bovine aortic endothelial (ABAE) cells, we have shown that transcription of rDNA in confluent cells falls to 5% of the transcription level in growing cells. Protein kinase NII appears to be a limiting factor to promote rDNA transcription in isolated nuclei of confluent cells. Protein kinase NII was detected by immunocytochemistry in the cytoplasm, nuclei and nucleoli of… CONTINUE READING
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