Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide.

@article{Stubbert2014ProteinKG,
  title={Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide.},
  author={Daniel Stubbert and Oleksandra Prysyazhna and Olena Rudyk and Jenna Scotcher and Joseph Robert Burgoyne and Philip Eaton},
  journal={Hypertension},
  year={2014},
  volume={64 6},
  pages={1344-51}
}
Dysregulated blood pressure control leading to hypertension is prevalent and is a risk factor for several common diseases. Fully understanding blood pressure regulation offers the possibility of developing rationale therapies to alleviate hypertension and associated disease risks. Although hydrogen sulfide (H2S) is a well-established endogenous vasodilator, the molecular basis of its blood-pressure lowering action is incompletely understood. H2S-dependent vasodilation and blood pressure… CONTINUE READING

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