Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.

@article{Azoitei2010ProteinKD,
  title={Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.},
  author={Ninel Azoitei and Ganesh Varma Pusapati and Alexander Kleger and Peter Moeller and Rainer Kuefer and Felicitas Genze and Martin Wagner and Johan Van Lint and Peter Carmeliet and Guido Adler and Thomas Seufferlein},
  journal={Gut},
  year={2010},
  volume={59 10},
  pages={
          1316-30
        }
}
BACKGROUND Tumour angiogenesis is crucially dependent on the communication between the tumour and the associated endothelium. Protein kinase D (PKD) isoenzymes mediate vascular endothelial growth factor-A (VEGF-A) induced endothelial cell proliferation and migration and are also highly expressed in various tumours. AIM To examine the role of PKDs for tumour proliferation and angiogenesis selectively in pancreatic and gastric tumours and in tumour-associated endothelium in vitro and in vivo… CONTINUE READING

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