Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation.

Abstract

HDAC7, a class II histone deacetylase that is highly expressed in thymocytes, inhibits both transcription of the orphan steroid nuclear receptor Nur77 and induction of apoptosis in response to activation of the T-cell receptor (TCR). Here, we report that HDAC7 is exported to the cytoplasm by a calcium-independent signaling pathway after TCR activation… (More)

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Cite this paper

@article{Parra2005ProteinKD, title={Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation.}, author={Maribel Parra and Herbert G. Kasler and Timothy A McKinsey and Eric N Olson and Eric Verdin}, journal={The Journal of biological chemistry}, year={2005}, volume={280 14}, pages={13762-70} }