Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts.

@article{Yoo2011ProteinKD,
  title={Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts.},
  author={James Yoo and Citlali Ekaterina Rodriguez Perez and Wenxian Nie and James Sinnett-Smith and Enrique Rozengurt},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={413 1},
  pages={
          30-5
        }
}
Stromal myofibroblasts regulate extracellular matrix components through the secretion of matrix metalloproteinases such as MMP-3. Both myofibroblasts and MMP-3 have been implicated in colonic inflammation and cancer but the regulatory signaling mechanism(s) are unknown. Exposure of the human colonic myofibroblast cell line 18Co to TNF-α and bradykinin induced synergistic MMP-3 mRNA and protein expression, which were blocked by the preferential PKC inhibitors GF109203X and Go6983 and by the MEK… CONTINUE READING
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