Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway.

  title={Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway.},
  author={Jeoung-Eun Park and Young-In Kim and A E Yi},
  journal={Journal of immunology},
  volume={182 10},
Protein kinase D1 (PKD1) has been shown to be involved in certain MAPK activation and cytokine expression by several TLR ligands. However, the precise physiological role of PKD1 in individual signaling from TLRs has not been fully addressed. In this study, we provide evidence that PKD1 is being activated by TLR ligands, except the TLR3 ligand. PKD1 activation by TLR ligands is dependent on MyD88, IL-1R-associated kinase 4 and 1, but independent of TNF-alpha receptor-associated factor 6. PKD1… CONTINUE READING
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