Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.

@article{Amadesi2009ProteinKD,
  title={Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.},
  author={Silvia Amadesi and Andrew Douglas Grant and Graeme S Cottrell and Natalya Vaksman and Daniel P Poole and Enrique 4 Rozengurt and Nigel W Bunnett},
  journal={The Journal of comparative neurology},
  year={2009},
  volume={516 2},
  pages={141-56}
}
Serine proteases generated during injury and inflammation cleave protease-activated receptor 2 (PAR(2)) on primary sensory neurons to induce neurogenic inflammation and hyperalgesia. Hyperalgesia requires sensitization of transient receptor potential vanilloid (TRPV) ion channels by mechanisms involving phospholipase C and protein kinase C (PKC). The protein kinase D (PKD) serine/threonine kinases are activated by diacylglycerol and PKCs and can phosphorylate TRPV1. Thus, PKDs may participate… CONTINUE READING

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