Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function.

@article{Haworth2004ProteinKD,
  title={Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function.},
  author={Robert S. Haworth and Friederike Cuello and Todd J. Herron and Gereon Franzen and Jonathan C Kentish and Mathias Gautel and Metin Avkiran},
  journal={Circulation research},
  year={2004},
  volume={95 11},
  pages={1091-9}
}
Protein kinase D (PKD) is a serine kinase whose myocardial substrates are unknown. Yeast 2-hybrid screening of a human cardiac library, using the PKD catalytic domain as bait, identified cardiac troponin I (cTnI), myosin-binding protein C (cMyBP-C), and telethonin as PKD-interacting proteins. In vitro phosphorylation assays revealed PKD-mediated phosphorylation of cTnI, cMyBP-C, and telethonin, as well as myomesin. Peptide mass fingerprint analysis of cTnI by liquid chromatography-coupled mass… CONTINUE READING

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