Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.

@article{LpezHuertas2011ProteinKC,
  title={Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.},
  author={Mar{\'i}a Rosa L{\'o}pez-Huertas and E Jim{\'e}nez Mateos and Gema D{\'i}az-Gil and Francisco G{\'o}mez-Esquer and Mar{\'i}a S{\'a}nchez del Cojo and Jos{\'e} Alcam{\'i} and Mayte Coiras},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 31},
  pages={27363-77}
}
Integration of HIV-1 genome in CD4(+) T cells produces latent reservoirs with long half-life that impedes the eradication of the infection. Control of viral replication is essential to reduce the size of latent reservoirs, mainly during primary infection when HIV-1 infects CD4(+) T cells massively. The addition of immunosuppressive agents to highly active antiretroviral therapy during primary infection would suppress HIV-1 replication by limiting T cell activation, but these agents show… CONTINUE READING
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