Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure.

@article{Goldspink2004ProteinKC,
  title={Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure.},
  author={Paul H. Goldspink and David Edward Montgomery and Lori A Walker and Dalia Urboniene and Ronald D. McKinney and David L. Geenen and R. John Solaro and Peter M. Buttrick},
  journal={Circulation research},
  year={2004},
  volume={95 4},
  pages={424-32}
}
We report characterization of a transgenic mouse that overexpresses constitutively active protein kinase Cepsilon in the heart and slowly develops a dilated cardiomyopathy with failure. The hemodynamic, mechanical, and biochemical properties of these hearts demonstrate a series of temporal events that mark the progression of the disease. In the 3-month transgenic (TG) animals, contractile properties and gene expression measurements are normal, but an increase in myofibrillar Ca2+ sensitivity… CONTINUE READING

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Protein Kinase C-β2 Augments Calcium Currents in Mouse Ventricular Myocytes

  • KJ Alden, PH Goldspink, PM Buttrick, J. Garcia
  • Am J Physiol Cell Physiol
  • 2002
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