Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.

Abstract

Lysophosphatidic acid (LPA), a potent bioactive lipid, elicits many of its biological actions via the specific G-protein-coupled receptors LPA1, LPA2, LPA3, and LPA4. Recently, we have shown that LPA-induced transactivation of platelet-derived growth factor receptor-beta is regulated by phospholipase D2 in human bronchial epithelial cells (HBEpCs) (Wang, L… (More)

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@article{Cummings2004ProteinKC, title={Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.}, author={R Harris Cummings and Yutong Zhao and David M P Jacoby and Ernst William Spannhake and M. Ohba and Joe G. N. Garcia and Tonya Watkins and Donghong He and Bahman Saatian and Viswanathan Natarajan}, journal={The Journal of biological chemistry}, year={2004}, volume={279 39}, pages={41085-94} }