Protein kinase Cdelta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle.

@article{Braiman1999ProteinKC,
  title={Protein kinase Cdelta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle.},
  author={Liora Braiman and Addy Alt and Toshio Kuroki and Motoi Ohba and Asia Bak and Tamar Tennenbaum and Sanford R. Sampson},
  journal={Molecular endocrinology},
  year={1999},
  volume={13 12},
  pages={2002-12}
}
Insulin activates certain protein kinase C (PKC) isoforms that are involved in insulin-induced glucose transport. In this study, we investigated the possibility that activation of PKCdelta by insulin participates in the mediation of insulin effects on glucose transport in skeletal muscle. Studies were performed on primary cultures of rat skeletal myotubes. The role of PKCdelta in insulin-induced glucose uptake was evaluated both by selective pharmacological blockade and by over-expression of… CONTINUE READING

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