Protein kinase Calpha participates in activation of store-operated Ca2+ channels in human glomerular mesangial cells.

@article{Ma2002ProteinKC,
  title={Protein kinase Calpha participates in activation of store-operated Ca2+ channels in human glomerular mesangial cells.},
  author={Rong Ma and Patrick E. Kudlacek and Steven C. Sansom},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 5},
  pages={C1390-8}
}
Protein kinase C (PKC) plays an important role in activating store-operated Ca2+ channels (SOC) in human mesangial cells (MC). The present study was performed to determine the specific isoform(s) of conventional PKC involved in activating SOC in MC. Fura 2 fluorescence ratiometry showed that the thapsigargin-induced Ca2+ entry (equivalent to SOC) was significantly inhibited by 1 microM Gö-6976 (a specific PKCalpha and betaI inhibitor) and PKCalpha antisense treatment (2.5 nM for 24-48 h… CONTINUE READING

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