Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.

@article{Johnson2007ProteinKC,
  title={Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.},
  author={Jolyn Johnson and Valentina Albarani and Muriel Nguyen and Michel Goldman and F. Th. C. Willems and Ezra Aksoy},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 20},
  pages={15022-32}
}
Protein kinase C (PKC) isoforms are critically involved in the regulation of innate immune responses. Herein, we investigated the role of conventional PKCalpha in the regulation of IFN-beta gene expression mediated by the Toll-like receptor 3 (TLR3) signaling pathway. Inhibition of conventional PKC (cPKC) activity in monocyte-derived dendritic cells or TLR3-expressing cells by an isoform-specific inhibitor, Gö6976, selectively inhibited IFN-beta synthesis induced by double-stranded RNA… CONTINUE READING

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