Protein kinase Calpha can undergo membrane localization via an alternative phosphatidylinositol 4,5-bisphosphate-dependent pathway.

@article{Son2006ProteinKC,
  title={Protein kinase Calpha can undergo membrane localization via an alternative phosphatidylinositol 4,5-bisphosphate-dependent pathway.},
  author={Hyowon Son and Yangmi Lim and Jinsook Kim and Haein Park and Sojoong Choi and Innoc Han and W Kim and Sungsu Park and Yunsoo Bae and E H Oh},
  journal={Archives of biochemistry and biophysics},
  year={2006},
  volume={454 1},
  pages={1-6}
}
Protein kinase Calpha (PKCalpha) activation is known to be dependent on the metabolic product of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC). Here we report that fibroblasts may have an additional PIP2-dependent mechanism for membrane localization of PKCalpha. We observed PKCalpha membrane localization in both wild type and… CONTINUE READING