Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability.

@article{Stamatovic2006ProteinKC,
  title={Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability.},
  author={Svetlana M. Stamatovic and Oliver B Dimitrijevic and Richard F. Keep and Anuska V. Andjelkovic},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 13},
  pages={
          8379-88
        }
}
Monocyte chemoattractant protein-1 (MCP-1 or CCL2) regulates blood-brain barrier permeability by inducing morphological and biochemical alterations in the tight junction (TJ) complex between brain endothelial cells. The present study used cultured brain endothelial cells to examine the signaling networks involved in the redistribution of TJ proteins (occludin, ZO-1, ZO-2, claudin-5) by CCL2. The CCL2-induced alterations in the brain endothelial barrier were associated with de novo Ser/Thr… CONTINUE READING
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