Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation.

@article{Orlandini1998ProteinKC,
  title={Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation.},
  author={Maurizio Orlandini and Francesca Semplici and R Ferruzzi and Flavio Meggio and Lorenzo A Pinna and Salvatore Oliviero},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 33},
  pages={21291-7}
}
Protein kinase CK2 is an ubiquitous and pleiotropic Ser/Thr protein kinase composed of two catalytic (alpha and/or alpha') and two noncatalytic (beta) subunits forming a heterotetrameric holoenzyme involved in cell growth and differentiation. Here we report the identification, cloning, and oncogenic activity of the murine CK2alpha' subunit. Serum treatment of quiescent mouse fibroblasts induces CK2alpha' mRNA expression, which peaks at 4 h. The kinetics of CK2alpha' expression correlate with… CONTINUE READING

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