Protein kinase CK2 as an ectokinase: the role of the regulatory CK2beta subunit.

@article{Rodrguez2008ProteinKC,
  title={Protein kinase CK2 as an ectokinase: the role of the regulatory CK2beta subunit.},
  author={Fernando Adri{\'a}n Rodr{\'i}guez and C Contreras and Victor M. Bolanos-Garcia and Jorge E. Allende},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 15},
  pages={5693-8}
}
Protein kinase CK2 (also known as casein kinase 2) is present in the cytoplasm, nuclei, and several other organelles. In addition, this enzyme has been found bound to the external side of the cell membrane where it acts as an ectokinase phosphorylating several extracellular proteins. Previous experiments with transfection of HEK-293T cells demonstrated that expression of both subunits, CK2alpha (catalytic) and CK2beta (regulatory), was necessary for the appearance of the ectopic enzyme as an… CONTINUE READING

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