Protein kinase CK2α is a target for the Abl and Bcr–Abl tyrosine kinases

@article{Hrich1998ProteinKC,
  title={Protein kinase CK2α is a target for the Abl and Bcr–Abl tyrosine kinases},
  author={Jean-Karim H{\'e}rich{\'e} and Edmond M. Chambaz},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={13-18}
}
Protein kinase CK2 is a ubiquitous serine-threonine kinase in which a catalytic α subunit often associates with a β subunit. CK2α is required for cell survival in yeast and has been proposed to be involved in cell growth control; however, its regulation in cells remains unclear. Here we present evidence that CK2α may be an associated substrate for the normal and oncogenic forms of the Abl tyrosine kinase. By probing CK2α with anti-phosphotyrosine antibodies, we found that CK2α can be… CONTINUE READING

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