Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells.

@article{Rahman2000ProteinKC,
  title={Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells.},
  author={Arshad Rahman and Khandaker N. Anwar and Asrar B. Malik},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={279 4},
  pages={C906-14}
}
We addressed the role of protein kinase C (PKC) isozymes in mediating tumor necrosis factor-alpha (TNF-alpha)-induced oxidant generation in endothelial cells, a requirement for nuclear factor-kappaB (NF-kappaB) activation and intercellular adhesion molecule-1 (ICAM-1) gene transcription. Depletion of the conventional (c) and novel (n) PKC isozymes following 24 h exposure of human pulmonary artery endothelial (HPAE) cells with the phorbol ester, phorbol 12-myristate 13-acetate (500 nM), failed… CONTINUE READING