Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.

@article{Beal2008ProteinKC,
  title={Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.},
  author={Allison M. Beal and Nadia Anikeeva and Rajat Varma and Thomas O. Cameron and Phillip J Norris and Michael L. Dustin and Yuri Sykulev},
  journal={Journal of immunology},
  year={2008},
  volume={181 7},
  pages={
          4815-24
        }
}
Destruction of virus-infected cells by CTL is an extremely sensitive and efficient process. Our previous data suggest that LFA-1-ICAM-1 interactions in the peripheral supramolecular activation cluster (pSMAC) of the immunological synapse mediate formation of a tight adhesion junction that might contribute to the sensitivity of target cell lysis by CTL. Herein, we compared more (CD8(+)) and less (CD4(+)) effective CTL to understand the molecular events that promote efficient target cell lysis… CONTINUE READING

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