Protein kinase C-theta is required for development of experimental cerebral malaria.

@article{Fauconnier2011ProteinKC,
  title={Protein kinase C-theta is required for development of experimental cerebral malaria.},
  author={Mathilde Fauconnier and Marie-Laure Bourigault and Sandra Meme and Frederic Szeremeta and Jennifer Palomo and Adeline Danneels and Sabine Charron and Lizette Fick and Muazzam Jacobs and Jean-Claude Beloeil and Bernhard Ryffel and Val{\'e}rie F J Quesniaux},
  journal={The American journal of pathology},
  year={2011},
  volume={178 1},
  pages={212-21}
}
Cerebral malaria is the most severe neurologic complication in children and young adults infected with Plasmodium falciparum. T-cell activation is required for development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (CM). To characterize the T-cell activation pathway involved, the role of protein kinase C-theta (PKC-θ) in experimental CM development was examined. PKC-θ-deficient mice are resistant to CM development. In the absence of PKC-θ, no neurologic sign of CM… CONTINUE READING
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