Protein kinase C-theta is required for NK cell activation and in vivo control of tumor progression.


Protein kinase C-theta (PKCtheta) was initially isolated as an important PKC isoform expressed in T cells, although its expression is not restricted to these cells. Despite the central function of PKCtheta in several immune responses, its role in the antitumor response against MHC class I (MHC-I)-negative cells has not been investigated. This is an… (More)
DOI: 10.4049/jimmunol.0801820


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