Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.

@article{BarouchBentov2005ProteinKC,
  title={Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.},
  author={Rina Barouch-Bentov and Edward E. Lemmens and Junru Hu and Edith M. Janssen and Nathalie M. Droin and Jianxun Song and Stephen P. Schoenberger and Amnon Altman},
  journal={Journal of immunology},
  year={2005},
  volume={175 8},
  pages={5126-34}
}
CD8(+) T cells are crucial for host defense against invading pathogens and malignancies. However, relatively little is known about intracellular signaling events that control the genetic program of their activation and differentiation. Using CD8(+) T cells from TCR-transgenic mice crossed to protein kinase C-theta (PKCtheta)-deficient mice, we report that PKCtheta is not required for Ag-induced CD8(+) T cell proliferation, but is important for T cell survival and differentiation into functional… CONTINUE READING

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