Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD.

@article{Bertolotto2000ProteinKC,
  title={Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD.},
  author={Corine Bertolotto and Laurence Maulon and Nathalie Filippa and Gottfried Baier and Patrick Auberger},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 47},
  pages={37246-50}
}
Both MAPK and protein kinase C (PKC) signaling pathways promote cell survival and protect against cell death. Here, we show that 12-O-tetradecanoylphorbol-13-acetate (TPA) prevents Fas-induced apoptosis in T lymphocytes. The effect of TPA was specifically abolished by the PKC inhibitor GF109203X and by dominant negative PKCtheta, PKCepsilon, and PKCalpha, suggesting that novel and conventional PKC isoforms mediate phorbol ester action. Moreover, TPA stimulated phosphorylation of BAD at serine… CONTINUE READING

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