Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368

Abstract

Phosphorylation of connexin43 (Cx43) on serine368 (S368) has been shown to decrease gap junctional communication via a reduction in unitary channel conductance. Examination of phosphoserine368 (pS368) in normal human skin tissue using a phosphorylation site-specific antibody showed relatively even distribution throughout the epidermal layers. However, 24 h… (More)

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@article{Richards2004ProteinKC, title={Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368}, author={Theresa S. Richards and Clarence A. Dunn and William Gene Carter and Marcia L. Usui and John E. Olerud and Paul D. Lampe}, journal={The Journal of Cell Biology}, year={2004}, volume={167}, pages={555 - 562} }