Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells

@article{SagiEisenberg1985ProteinKC,
  title={Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells},
  author={Ronit Sagi-Eisenberg and Harry Lieman and Israel Pecht},
  journal={Nature},
  year={1985},
  volume={313},
  pages={59-60}
}
It has been proposed that protein kinase C mediates cellular responses evoked by external stimuli, leading to alterations in internal free calcium concentrations1–4. We have shown previously that histamine-secreting rat basophilic leukaemia cells (RBL-2H3), which degranulate on aggregation of the receptors for immunoglobulin IgE5, contain a Ca2+- and phospholipid-dependent protein kinase (kinase C)6,7. The partially purified enzyme is activated directly by the tumour-promoting phorbol ester 12… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Role of epithelial Na+ channels in endothelial function.

Journal of cell science • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…