Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.

@article{Topham1998ProteinKC,
  title={Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.},
  author={Matthew K. Topham and Michaeline Bunting and Guy A Zimmerman and Thomas M McIntyre and Jr. P. Blackshear and Stephen M. Prescott},
  journal={Nature},
  year={1998},
  volume={394 6694},
  pages={
          697-700
        }
}
Diacylglycerol kinases (DGKs) terminate signalling from diacylglycerol by converting it to phosphatidic acid. Diacylglycerol regulates cell growth and differentiation, and its transient accumulation in the nucleus may be particularly important in this regulation. Here we show that a fraction of DGK-zeta is found in the nucleus, where it regulates the amount of nuclear diacylglycerol. Reducing nuclear diacylglycerol levels by conditional expression of DGK-zeta attenuates cell growth. The nuclear… CONTINUE READING

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