Protein kinase C regulates endocytosis and recycling of E-cadherin.

  title={Protein kinase C regulates endocytosis and recycling of E-cadherin.},
  author={Tam Luan Le and Shannon R Joseph and Alpha S. Yap and Jennifer L Stow},
  journal={American journal of physiology. Cell physiology},
  volume={283 2},
E-cadherin is a major component of adherens junctions in epithelial cells. We showed previously that a pool of cell surface E-cadherin is constitutively internalized and recycled back to the surface. In the present study, we investigated the potential role of protein kinase C (PKC) in regulating the trafficking of surface E-cadherin in Madin-Darby canine kidney cells. Using surface biotinylation and immunofluorescence, we found that treatment of cells with phorbol esters increased the rate of… CONTINUE READING


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