Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression.

@article{Song2015ProteinKC,
  title={Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression.},
  author={Xiang Song and Xiaoqian Qian and M. Shen and Rong Jiang and M. Wagner and Guoliang Ding and G. Chen and B. Shen},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1853 2},
  pages={
          513-21
        }
}
Protein kinase C (PKC) and galectin-3 are two important mediators that play a key pathogenic role in cardiac hypertrophy and heart failure (HF). However, the molecular mechanisms and signaling pathways are not fully understood. In this study, we explored the relationship between and roles of PKC-α and galectin-3 in the development of HF. We found that activation of PKC by phorbol dibutyrate (PDB) increased galectin-3 expression by ~180%, as well as collagen I and fibronection accumulation in… Expand
Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF-κB/c-fos signaling pathway
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