Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

@article{Bhave2003ProteinKC,
  title={Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).},
  author={Gautam Bhave and H Hu and Kathi S Glauner and Weiguo Zhu and Haibin Wang and Daniel James Brasier and Gerry Stephen Oxford and Robert W Gereau},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 21},
  pages={12480-5}
}
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the channel is activated by capsaicin. In addition, studies have suggested that phosphorylation by PKC might directly gate the channel, because PKC-activating phorbol esters induce TRPV1 currents in the absence of applied ligands. To test whether PKC both modulates and gates the TRPV1 function by direct phosphorylation, we… CONTINUE READING
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