Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.

@article{Chung2000ProteinKC,
  title={Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.},
  author={Sang-Hyuk Chung and J{\'a}nos Polg{\'a}r and Guy L Reed},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 33},
  pages={25286-91}
}
We postulated that the syntaxins, because of their key role in SNARE complex formation and exocytosis, could be important targets for signaling by intracellular kinases involved in secretion. We found that syntaxin 4 was phosphorylated in human platelets treated with a physiologic agent that induces secretion (thrombin) but not when they were treated with an agent that prevents secretion (prostacyclin). Syntaxin 4 phosphorylation was blocked by inhibitors of activated protein kinase C (PKC… CONTINUE READING

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