Protein kinase C pathway is involved in the inhibition by crocetin of vascular smooth muscle cells proliferation.


Crocetin is a natural carotenoid compound isolated from Gardenia jasminoids Ellis. Our previous study showed that crocetin inhibits angiotensin II (Ang II)-induced proliferation of vascular smooth muscle cells (VSMCs). The present study investigated the involvement of the protein kinase C (PKC) pathway in the growth-inhibitory action of crocetin in VSMCs… (More)
DOI: 10.1002/ptr.3194

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