Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.

@article{Thorneloe2002ProteinKC,
  title={Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.},
  author={Kevin S. Thorneloe and Yoshiaki Maruyama and Andrew Todd Malcolm and Peter E. Light and M. P. Walsh and William C. Cole},
  journal={The Journal of physiology},
  year={2002},
  volume={541 Pt 1},
  pages={65-80}
}
The molecular identity of smooth muscle ATP-sensitive K(+) channels (K(ATP)) is not established with certainty. Patch clamp methods were employed to determine if recombinant K(ATP) channels composed of Kir6.1 and SUR2B subunits expressed by human embryonic kidney (HEK293) cells share an identical modulation by protein kinase C (PKC) with the vascular K(NDP) subtype of K(ATP) channel. The open probability of Kir6.1/SUR2B channels was determined before and after sequential exposure to pinacidil… CONTINUE READING

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