Protein kinase C modulates the amounts of IL-1 receptor mRNA in human lung fibroblasts.

@article{Aksamit1993ProteinKC,
  title={Protein kinase C modulates the amounts of IL-1 receptor mRNA in human lung fibroblasts.},
  author={Timothy R. Aksamit and Martha M. Monick and Gary W. Hunninghake},
  journal={Journal of immunology},
  year={1993},
  volume={151 1},
  pages={284-90}
}
IL-1 activates human lung fibroblasts via IL-1-specific membrane receptors. The numbers of IL-1 binding sites on fibroblasts are increased after exposure to prostaglandin E2 (PGE2) or IL-1. Increases in binding sites are associated with changes in functional responses to IL-1. In these studies, we determined if alterations in numbers of IL-1 binding sites… CONTINUE READING