Protein kinase C modulates telomerase activity in human cervical cancer cells

@article{Kim2001ProteinKC,
  title={Protein kinase C modulates telomerase activity in human cervical cancer cells},
  author={Yong Wook Kim and Soo Young Hur and Tae Eung Kim and Joon mo Lee and Sung Eun Namkoong and In-Kyung Kim and Jin Woo Kim},
  journal={Experimental & Molecular Medicine},
  year={2001},
  volume={33},
  pages={156-163}
}
Telomerase, a ribonucleoprotein reverse transcriptase that extends telomeres of eukaryotic chromosomes is repressed in normal somatic cells but is activated during development and neoplasia. The regulation mechanism of telomerase activity in cancer cells is not clearly known. In this report, a possible affect of PKC on telomerase activity was examined using HeLa and CUMC-6 cervical cancer cell lines. Exposure of cells to PKC inhibitor, bisindolylmaleimide I and Go6976, and high levels of PKC… CONTINUE READING
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