Protein kinase C mediates the inhibitory effect of substance P on HCO3- secretion from guinea pig pancreatic ducts.

@article{Hegyi2005ProteinKC,
  title={Protein kinase C mediates the inhibitory effect of substance P on HCO3- secretion from guinea pig pancreatic ducts.},
  author={P{\'e}ter Hegyi and Zolt{\'a}n Rakonczay and Laszlo Tiszlavicz and Andr{\'a}s Varr{\'o} and Andras Toth and G{\'a}bor R{\'a}cz and G{\'a}bor Varga and Michael A. Gray and Barry E. Argent},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={288 5},
  pages={C1030-41}
}
The inhibitory control of pancreatic ductal HCO(3)(-) secretion may be physiologically important in terms of limiting the hydrostatic pressure developed within the ducts and in terms of switching off pancreatic secretion after a meal. Substance P (SP) inhibits secretin-stimulated HCO(3)(-) secretion by modulating a Cl(-)-dependent HCO(3)(-) efflux step at the apical membrane of the duct cell (Hegyi P, Gray MA, and Argent BE. Am J Physiol Cell Physiol 285: C268-C276, 2003). In the present study… CONTINUE READING

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