Protein kinase C-mediated necrosis–apoptosis switch of cortical neurons by conditioned medium factors secreted under the serum-free stress

@article{Fujita2003ProteinKC,
  title={Protein kinase C-mediated necrosis–apoptosis switch of cortical neurons by conditioned medium factors secreted under the serum-free stress},
  author={Ryousuke Fujita and Hiroshi Ueda},
  journal={Cell Death and Differentiation},
  year={2003},
  volume={10},
  pages={782-790}
}
AbstractCortical neurons die in necrosis in the low-density (LD) culture, and in apoptosis in the high-density (HD) culture under the serum-free condition without any supplements. The neuronal death in LD culture was delayed by conditioned medium (CM) factors prepared from the HD culture. The CM switched the cell death mode from necrosis to apoptosis, characterized by various cell death markers and transmission electron microscopy. The CM inhibited the rapid decrease in cellular ATP levels and… CONTINUE READING