Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells.

@article{Tan1991ProteinKC,
  title={Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells.},
  author={Yusuf P. Tan and Alain Marty},
  journal={The Journal of physiology},
  year={1991},
  volume={433},
  pages={357-71}
}
1. Desensitization of the Ca2+ release response evoked by acetylcholine in acinar cells from rat lacrimal glands was studied using the Ca(2+)-sensitive dye Fura-2. The evolution of the amplitude and half-maximal rise time (t1/2) of the Ca2+ response was followed as a function of trial number in a series of stimulations. 2. Under control conditions repetitive applications of acetylcholine (15 s long applications every minute) led to a linear decrease of the amplitude and to a linear increase of… CONTINUE READING