Protein kinase C masks nitric oxide synthase activity in vascular smooth muscle under basal conditions.

Abstract

Under basal conditions there is no observable nitric oxide synthase (NOS) activity in vascular smooth muscle (VSM). Pretreatment of endothelium-denuded aortic rings from Sprague-Dawley rats with 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), (0.1 micromol/L) significantly attenuated phenylephrine (PE)-induced contractile responses in a dose-dependent… (More)

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@article{Kline2004ProteinKC, title={Protein kinase C masks nitric oxide synthase activity in vascular smooth muscle under basal conditions.}, author={Loren W. Kline and Junzhi Ji and G J Wang and Sharla K. Sutherland and Peter K. T. Pang and Christina G. Benishin}, journal={Journal of cardiovascular pharmacology}, year={2004}, volume={43 2}, pages={281-7} }