Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells.

@article{Frey1997ProteinKC,
  title={Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells.},
  author={Mark R Frey and Marian L. Saxon and Xiuhua Zhao and Andrew Rollins and Sharon S Evans and Jennifer D. Black},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 14},
  pages={
          9424-35
        }
}
The molecular mechanisms underlying protein kinase C (PKC) isozyme-mediated control of cell growth and cell cycle progression are poorly understood. Our previous analysis of PKC isozyme regulation in the intestinal epithelium in situ revealed that multiple members of the PKC family undergo changes in expression and subcellular distribution precisely as the cells cease proliferating in the mid-crypt region, suggesting that activation of one or more of these molecules is involved in negative… CONTINUE READING
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