Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer.

@article{Assender2007ProteinKC,
  title={Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer.},
  author={Jean W. Assender and Julia M. W. Gee and I S Lewis and Ian O. Ellis and John F. R. Robertson and Robert Ian Nicholson},
  journal={Journal of clinical pathology},
  year={2007},
  volume={60 11},
  pages={1216-21}
}
BACKGROUND Although in vitro breast cancer models have demonstrated a role for protein kinase C (PKC) alpha and delta isoforms in endocrine insensitivity and resistance respectively, there is currently little clinical evidence to support these observations. AIMS To define the pattern of PKC alpha and delta expression using breast cancer cell lines, with and without endocrine resistance, and also breast cancer samples, where expression can be correlated with clinicopathological and endocrine… CONTINUE READING
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