Protein kinase C is involved in the early signals of interferon-alpha but not of interferon-gamma in U937 cells.

@article{Csermely1990ProteinKC,
  title={Protein kinase C is involved in the early signals of interferon-alpha but not of interferon-gamma in U937 cells.},
  author={P{\'e}ter Csermely and Elisabeth Balint and Philip M. Grimley and Adorjan Aszalos},
  journal={Journal of interferon research},
  year={1990},
  volume={10 6},
  pages={605-11}
}
Increasing interest is being focused on the role of protein kinase C (PKC) in the mode of action of interferons (IFNs). Here we report that IFN-alpha induced a transient translocation of PKC from the cytosol to the particulate fraction of U937 cells. In contrast, after IFN-gamma treatment, no significant change in PKC activity could be observed. IFN-induced changes in membrane potential were also examined by means of a potential sensitive oxonal dye and flow cytometry. Hyperpolarization was… CONTINUE READING