Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro.

@article{Rosales1992ProteinKC,
  title={Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro.},
  author={Oscar R Rosales and Bauer E. Sumpio},
  journal={Surgery},
  year={1992},
  volume={112 2},
  pages={459-66}
}
BACKGROUND The mechanism by which hemodynamic forces influence the function of the endothelium lining a blood vessel are unknown. The aim of this study was to determine the effect of in vitro cyclic strain on endothelial cell (EC) activation of protein kinase C (PKC). METHODS Confluent bovine aortic ECs grown on flexible-bottomed culture plates were subjected to 24% maximum strain at a frequency of 60 cycles/min for 24 hours. Changes in PKC activity and evidence of translocation from cytosol… CONTINUE READING
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