Protein kinase C inhibits Kv1.1 potassium channel function.

  title={Protein kinase C inhibits Kv1.1 potassium channel function.},
  author={Linda M. Boland and Katharine A Jackson},
  journal={American journal of physiology. Cell physiology},
  volume={277 1},
The regulation by protein kinase C (PKC) of recombinant voltage-gated potassium (K) channels in frog oocytes was studied. Phorbol 12-myristate 13-acetate (PMA; 500 nM), an activator of PKC, caused persistent and large (up to 90%) inhibition of mouse, rat, and fly Shaker K currents. K current inhibition by PMA was blocked by inhibitors of PKC, and inhibition was not observed in control experiments with PMA analogs that do not activate PKC. However, site-directed substitution of potential PKC… CONTINUE READING
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