Protein kinase C in synaptic plasticity: Changes in the in situ phosphorylation state of identified pre- and postsynaptic substrates

@article{Ramakers1997ProteinKC,
  title={Protein kinase C in synaptic plasticity: Changes in the in situ phosphorylation state of identified pre- and postsynaptic substrates},
  author={Geert M. J. Ramakers and Piera Pasinelli and J J Hens and Willem Hendrik Gispen and P. N. E. Graan},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1997},
  volume={21},
  pages={455-486}
}
1. Long-term potentiation and its counterpart long-term depression are two forms of activity dependent synaptic plasticity, in which protein kinases and protein phosphatases are essential. 2. B-50/GAP-43 and RC3/neurogranin are two defined neuronal PKC substrates with different synaptic localization. B-50/GAP-43 is a presynaptic protein and RC3/neurogranin is only found at the postsynaptic site. Measuring their phosphorylation state in hippocampal slices, allows us to simultaneously monitor… CONTINUE READING

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References

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De Graan: Protein Kinase C in synaptic plasticity: changes in the in situ phosphorylation state of identified pre- and postsynaptic substrates

Ramakers, Geert M.J, +3 authors Pierre N.E
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