Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.

@article{Jansen2001ProteinKC,
  title={Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.},
  author={Aaron P. Jansen and Eric G. Verwiebe and Nancy Ellen Dreckschmidt and Deric L Wheeler and Terry D. Oberley and Ajit K. Verma},
  journal={Cancer research},
  year={2001},
  volume={61 3},
  pages={808-12}
}
Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the most common forms of human skin cancer. BCC is slow growing and mostly localized, whereas SCC metastasizes to the regional lymph nodes and subsequently to distal organs. In murine skin carcinogenesis models for SCC, the incidence of metastasis is very low. We report here that FVB/N transgenic mice, which overexpress (approximately 18-fold) epitope-tagged protein kinase C-epsilon (T7-PKCepsilon) protein in the epidermis provide… CONTINUE READING
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