Protein kinase C effects on nerve function, perfusion, Na+,K+-ATPase activity and glutathione content in diabetic rats

@article{Cameron1999ProteinKC,
  title={Protein kinase C effects on nerve function, perfusion, Na+,K+-ATPase activity and glutathione content in diabetic rats},
  author={Norman E Cameron and Mary A. Cotter and Alison M Jack and Michael D Basso and Thomas C. Hohman},
  journal={Diabetologia},
  year={1999},
  volume={42},
  pages={1120-1130}
}
Aims//hypothesis. Increased protein kinase C activity has been linked to diabetic vascular complications in the retina and kidney, which were attenuated by protein kinase C antagonist treatment. Neuropathy has a vascular component, therefore, the aim was to assess whether treatment with WAY151 003 or chelerythrine, inhibitors of protein kinase C regulatory and catalytic domains respectively, could correct nerve blood flow, conduction velocity, Na+,K+-ATPase, and glutathione deficits in diabetic… CONTINUE READING
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Effect of a protein kinase C-b specific inhibitor on diabetic neuropathy in rats. Diabetes 47 [Suppl 1]: A70

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1 Excerpt

Effect of a protein kinase Cb specific inhibitor on diabetic neuropathy in rats

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Effects of the protein kinase Cb inhibitor, LY333531, on nerve and vascular function in diabetic rats

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  • Diabetologia
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2 Excerpts

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