Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells.

@article{Kubitz2001ProteinKC,
  title={Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells.},
  author={Ralf Kubitz and Christopher Huth and Marcus M Schmitt and Axel Horbach and Gerd-Achim Kullak-Ublick and Dieter H{\"a}ussinger},
  journal={Hepatology},
  year={2001},
  volume={34 2},
  pages={340-50}
}
The subcellular localization of hepatobiliary transport proteins directly affects the rate of bile formation, e.g., the conjugate export pump multidrug resistance protein 2 (MRP2) is regulated on a short-term scale by retrieval from and insertion into the canalicular membrane in the liver. This study reports on the effects of protein kinase C on MRP2 localization and activity in human hepatoblastoma HepG2 cells. MRP2 was detected in HepG2 cells by immunocytochemistry and Western blot analysis… CONTINUE READING
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