Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation.

@article{Potter1994ProteinKC,
  title={Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation.},
  author={Lincoln Ross Potter and David L. Garbers},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 20},
  pages={14636-42}
}
Stimulation of guanylyl cyclase A (GC-A) by atrial natriuretic peptide (ANP) is antagonized by activators of protein kinase C (PKC). Thus, it has been suggested that PKC phosphorylates and desensitizes GC-A. Here, we have developed stable GC-A transfectants of NIH3T3 cells, which display marked reductions in hormone-dependent cGMP elevations and guanylyl cyclase activity after incubation with ANP or phorbol 12-myristate 13-acetate (PMA). ANP binding and immunoblot analysis indicated that the… CONTINUE READING
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